Endoparasites are parasites of organs within the host, such as the digestive tract, liver, lungs, and bladder, or parasites within tissue cells. For example, Enterobius vermicularis parasites in the intestine, Trichinella spiralis larvae in the transverse muscle tissue and Toxoplasma gondii in various nucleated cells. Endoparasites are harmful to the host by taking nutrients, disrupting digestive and excretory systems, drawing blood, toxic effects of toxins, mechanical damage and obstruction, and introducing other pathogens. The combination of these hazards may cause the host's growth and development to be impaired, the body's resistance to decline, susceptibility to other diseases, and in severe cases, to stop eating or even die. More and more research is focused on endoparasites, meticulously studying pathogenesis, anthelmintic drugs, and vaccine development.

Ace Therapeutics is a specialist in the field of parasites, providing multi-omics services for endoparasites, including but not limited to genomics, epigenomics, transcriptomics, proteomics, and metabolomics. The aim is to resolve the biological aspects of endoparasites at the molecular level. Every step from sample extraction, and library sequencing, to data analysis, has been scientifically and meticulously designed to guarantee high-quality research results.

Multi-Omics Service Options for Endoparasites

1. Transcriptomics

We provide transcriptome services for endoparasites, such as scRNA-seq, spatial transcriptome sequencing, mRNA-seq, lncRNA-seq, circRNA-seq, small RNA-seq, and whole transcriptome sequencing, which can help you comprehensively explore the gene transcription and regulatory mechanisms of endoparasite evolution and pathogenesis, and provide a theoretical basis for the development of anthelmintic drugs and vaccines. For example, transcriptomic services for ascarid, tapeworms, hookworms, pinworms, Giardia lamblia, Endolymphatic amoebae, schistosome, toxoplasma, and Wuchereria bancrofti.

2. Epigenomics

We provide epigenomics services for endoparasites, including ChlP-seq, RIP-seq, ATAC-seq, MeRlP-seq, and single-cell ATAC-seq. We mainly analyze changes in gene expression levels based on non-genetic sequence alterations, such as DNA methylation and chromatin conformational changes. To study the molecular mechanisms of gene expression/regulation/genetics and biological processes such as development, reproduction, and disease development, and to deeply resolve biological issues such as the relationship between the parasitic environment of endophytic parasites and disease occurrence.

3. Proteomics

We provide proteomics services for endoparasites, including iTRAQ/TMT-labeled quantitative proteomics, label-free quantitative proteomics, DIA quantitative proteomics, qualitative recognition proteomics, and qualitative modification proteomics. We focus on protein composition and changes in endoparasites during evolution, nutrient acquisition, pathogenesis, and treatment, as well as parasite-host interaction studies to provide a theoretical basis for finding biomarkers.

4. Metabolomics

We provide metabolomics services for endoparasites, including both targeted and non-targeted metabolomics. We mainly analyze the biology of endoparasites in terms of nutrition and metabolism, parasite toxins, and pathogenicity.

5. Genomics

We provide genome sequencing services for endoparasites, including next-generation library building and sequencing and third-generation library building and sequencing. It is mainly used to study the whole genome assembly and annotation of certain endoparasites, as well as evolutionary analysis and individual genomic variation detection. On this basis, we help you to explore biological questions related to evolution and pathogenesis. For example, genomic services for heartworm, hookworm, pinworm, whipworm, tapeworm, coccidia, ascarid, nematode, and toxoplasma.

Endoparasites

We can provide multi-omics services for endoparasites including but not limited to those listed below:

• Endoparasites of the digestive tract, such as ascarid, tapeworms, hookworms, Giardia lamblia, and endolymphatic amoebae.
• Intraluminal parasites, such as Trichomonas vaginalis.
• Intrahepatic parasites, such as liver flukes, encysted worms
• Intra-pulmonary parasites, such as Schistosoma iridium.
• Brain tissue parasites, such as cercariae, and Toxoplasma gondii.
• Intravascular parasites, such as schistosomes.
• Intralymphatic parasites, such as filarial worms.
• Muscle tissue parasites, such as trichinella larvae.
• Intracellular parasites, such as plasmodium and leishmania.
• Bone tissue parasites, such as encrusting worms.
• Skin parasites, such as scabies mites.
• Intraocular parasites, such as porcine cysticerci and sucking nematodes.

Service Details

• Sample type: mostly, the samples are studied before/mid/post the evolution/disease of endoparasites, or choose the sample type according to your research purpose.
• Delivery content: experiment report.
• Service fee: please get it through online inquiry.

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service