Schistosoma, also known as schistosomes, are all parasitic, mostly endoparasitic and a few ectoparasitic, with adults living in the veins of humans or mammals. There are three main species of schistosomes parasitizing humans, namely Schistosoma japonicum, Schistosoma mansoni and Schistosoma haematobium. Schistosomiasis is a parasitic disease that seriously endangers human health and is prevalent in 76 countries and regions in the tropics and subtropics.

The transcriptome is a collection of gene transcription information of cells at a physiological period and a specific developmental stage. In-depth study of the transcriptome is important for studying the functions of certain genes in the genome, revealing the composition of certain molecules in cells or tissues, and studying the development and disease processes of the organism.

Ace Therapeutics provided transcriptome level sequencing and analysis services for schistosomes, aiming to investigate the developmental biology, pathogenesis, and schistosome-host interaction mechanism of schistosomes at the transcriptional level. It opens up avenues for further isolation and identification of key functional genes in the genome of schistosomes, and for mining new anti-schistosomiasis drug targets and vaccine candidate molecules. It provides a theoretical basis for the translation of schistosomiasis animal model research results to the prevention and treatment of schistosomiasis in humans or domestic animal.

Transcriptome Sequencing Service Options for Schistosomes

• Transcriptome sequencing service for schistosome without reference genome
• Transcriptome sequencing service for schistosome with reference genome
• Full-length transcriptome sequencing service for schistosome
• mRNA sequencing service for schistosome
• LncRNA sequencing service for schistosome
• CircRNA sequencing service for schistosome
• Small RNA sequencing service for schistosome
• Whole transcriptome sequencing service for schistosome

We provide transcriptome sequencing and analysis services for schistosomes with/without reference genome and full-length transcriptome sequencing and analysis services using high-throughput sequencing technology to accurately decipher the structural information of mRNA, overcome the problems of short splicing and incomplete transcript information for species without reference genome, and achieve homologous isoform analysis, single-base variation detection, variable splicing analysis, homologous The Dual RNA-seq can be used to identify homologs, single base variants, variable splicing, homologs and alleles of schistosomes. We also provide sequencing and analysis services for lncRNA-Seq, small RNA-Seq, circRNA-Seq and other types of transcriptomics to achieve identification, quantification and functional analysis of lncRNA, small RNA and circRNA. We can also perform multi-omics integration analysis, such as lncRNA+small RNA+circRNA, lncRNA+small RNA, lncRNA-Seq+small RNA+circRNA. We can extend the study of gene regulatory mechanisms to a three-dimensional model of the "net".

• Dual RNA sequencing service for schistosome

Dual RNA-seq eliminates the need to separate two species, avoiding the interference caused by separation. By constructing only one transcriptome library, we can sequence and analyze 2 (or more) species simultaneously, thus revealing the dynamic changes of gene expression between schistosomes-hosts. At the same time, the regulatory relationship of genes between species can be obtained from the intercropping model map, and the mechanism of interaction between the two species can be obtained.

We have more than 10 years of project experience and multiple sequencing platforms for you to choose flexibly. We can also perform integrated multi-omics analysis to solve the biological problem of schistosome gene regulation in one-stop. We also have the flexibility to perform personalized information analysis in conjunction with customer needs.

Service Details

Sample requirements: each service is with independent sample requirements, please consult our technical engineers or sales staff for details.
Delivery content: experiment report.
Test fee: please get it through online inquiry.

Service Flow

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service