Hookworms are the collective name for nematodes of the family Hookwormidae, and the well-developed oral cysts are their morphological characteristics. Among the nematodes that parasitize the human digestive tract, hookworm is the most harmful. It is able to enter the body through the skin and then reach the intestine. They feed on human blood and can survive in the intestine for many years. Hookworms can cause health problems such as anemia and malnutrition, and are particularly dangerous for children and pregnant women. Hookworms have a worldwide distribution, especially in tropical and subtropical regions, where infections are more common in the population. The main parasites in humans are Ancylostoma duodenale and Necator americanus Stiles. In addition, Ancylostoma ceylanicum Loose, which can occasionally parasitize humans, is similar to the first two hookworms in its harmfulness. The infective stages of Ancylostoma caninum Ercolani and Aucylostoma braziliense Gomezde Faria can also invade humans and cause cutaneous larva migrans (CLM). Because the larvae migrate sinuously and bend, causing a rash in the form of runner lines, so called creeping eruption. However, the larvae cannot develop into adult worms. Transcriptome sequencing of hookworms can identify new therapeutic targets, which will greatly accelerate the development of anti-hookworm drugs and vaccines.

Ace Therapeutics provides transcriptome sequencing and analysis services for hookworm, aiming to contribute to the study of gene expression abundance detection and structural analysis, functional gene mining, and gene regulation mechanism research of hookworm, to promote more in-depth gene expression research, and to provide more valuable information for the molecular mechanism of hookworm-host interaction and the development of anti-hookworm drugs for animals.

Transcriptome Sequencing Service Options for Hookworm

• Transcriptome sequencing service for hookworm without reference genome
• Transcriptome sequencing service for hookworm with reference genome

We used high-throughput sequencing technology for cDNA sequencing of hookworms to obtain transcripts relatively quickly. Transcript sequencing is currently available separately for hookworms with or without reference genomes.

• Small RNA sequencing service for hookworm

We focus on miRNA, siRNA and piRNA detection and analysis to study the physiological processes of hookworm such as gene expression and regulation, individual development, metabolism and disease development. We provide a powerful tool to study the function of small RNA and gene regulation mechanism of hookworm.

• LncRNA sequencing service for hookworm

We use lncRNA sequencing of hookworm to quickly obtain lncRNA expression changes related to host biological processes or diseases, facilitating their in-depth study.

• CircRNA sequencing service for hookworm

We have used the identification, expression abundance detection and structural analysis of circRNA of hookworm to study its regulatory role on miRNA and its regulatory expression on genes, and to promote more in-depth gene expression studies.

• Whole transcriptome sequencing service for hookworm

We sequenced the whole transcriptome (mRNA, lncRNA, circRNA and microRNA) of Hookworm to explore the underlying regulatory network mechanisms and uncover transcriptional regulation to study the immune mechanism, developmental evolution, pathogenesis, and drug targets of hookworm.

• Full-length transcriptome sequencing service for hookworm

We provide full-length transcriptome sequencing and analysis services for hookworm based on PacBio triple sequencing platform, which can directly obtain the full-length sequence of mRNA and can more accurately decipher the structural information of mRNA, achieve homologous isoform analysis, single base variant detection, variable splicing analysis, homologous gene identification and allele identification of hookworm.

Service Details

Sample requirements: each service is with independent sample requirements, please consult our technical engineers or sales staff for details.
Delivery content: experiment report.
Test fee: please get it through online inquiry .

Service Flow

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service