Soil-derived parasites are parasites whose life history does not require an intermediate host and whose developmental stage before entering the animal/human body takes place in the external environment (strictly speaking, in the soil), that is, the pathogen develops in the external natural environment until the infection stage and then infects the human body directly. There are mainly soil-derived nematodes and soil-derived protozoa.

There are many reports revolving around soil-derived parasites, mainly: to study the growth and developmental mechanisms of soil-derived parasites to block their developmental process to reduce infection. To study the infection mechanism of soil-derived parasites to hinder their infection pathway to reduce infection. To study the pathogenic mechanism of soil-derived parasites to target their pathogenic factors to reduce the disease, etc.

Ace Therapeutics provides a one-stop shop for multi-omics of soil-derived parasites, including but not limited to genomics, epigenomics, transcriptomics, proteomics, metabolomics, and single-cell omics. Each step from sample extraction, library construction, sequencing/assay to data analysis is scientifically and carefully designed to ensure the reliability of the results.

Multi-Omics Service Options for Soil-borne Parasites

1. Transcriptomics

Using transcriptomics technology, we can detect genes expressed by soil-derived parasites during growth and development, before and after infection, and during survival in the host, which is the basis for studying the physiology and pathogenesis of soil-derived parasites. We can analyze the gene expression differences of soil-derived parasites under different developmental stages, different environments, and other conditions, and also realize gene annotation and transcriptional regulatory network mapping. Efficient functional gene mining provides a strong basis for targeted drug and vaccine development for soil-derived parasites. The transcriptome sequencing services we can provide for soil-derived parasites include but are not limited to scRNA-seq, RNA-seq, lncRNA-seq, circRNA-seq, small RNA-seq, whole transcriptome sequencing, and comparative transcriptome sequencing. For example, transcriptomic services for ascarid, hookworms, pinworms, Giardia lamblia, and Endolymphatic amoebae.

2. Epigenomics

Using epigenetic techniques, we can search for DNA/RNA binding sites of target proteins from genome-wide or changes in gene expression levels of non-genetic sequence alterations (e.g. DNA methylation and chromatin conformation changes) for soil-derived parasites, providing effective methods for studying gene regulation, DNA/RNA imprinting, etc. We provide efficient data support for studying the molecular mechanisms of gene expression /regulation /genetics and biological processes such as development, reproduction, disease occurrence, and parasitic environmental changes. We provide epigenomics services for soil-derived parasites, including ChlP-seq, RIP-seq, ATAC-seq, MeRlP-seq, and single-cell ATAC-seq.

Options for Soil-borne Parasites

Soil-borne parasites that we can serve include but are not limited to:

• Soil-borne nematodes
  Ascaris, whipworms, hookworms, pinworms, hepatic capillary nematodes, fecal roundworms, etc.
• Soil-borne protozoa
  Endolymphatic amoebae, Giardia lamblia, Cryptosporidium, Trichuris trichiura, etc.

Service Details

• Sample type: in most cases, the samples are the growth and developmental processes, before and after infection, disease progression of soil-borne parasites, etc., or the sample type is chosen according to the purpose of your study.
• Delivery content: experiment report.
• Service fee: please get it through online inquiry.

Service Flow

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service