Parasitic diseases are a serious public health problem worldwide. Traditional treatment methods are time-consuming and difficult to completely remove the pathogens. Therefore, the development of effective parasitic vaccines has become necessary to address such diseases. Internationally, research on vaccines against various parasites has received extensive attention. For example, progress has been made in vaccine research against a variety of parasites such as malaria, schistosomes, and filarial worms. Many major biotechnologies such as genetic engineering, immunology, and cytology are used in these studies.

Ace Therapeutics provides solutions for parasitic vaccine development research to help our clients rapidly and efficiently conduct research and development to advance parasitic vaccine development. Ace Therapeutics has a dedicated team of post-docs, scientists, and technologists to provide a full range of parasitic vaccine development services. Meanwhile, we have a series of advanced and reliable technology platforms, such as genetic engineering, immunology, and cytology, to meet the different needs of our customers. In addition, we have a well-established quality management system and compliance assurance system that can ensure high-quality project execution.

Solution Options for Parasitic Disease Vaccine Development Research

For parasite vaccine development studies, Ace Therapeutics offers a variety of solutions, including but not limited to the following:

• Study of antigenic epitopes of parasitic viroids

Current developments in histological technologies have made it possible to perform a comprehensive analysis of parasitic viroids. We can provide technical services to resolve antigenic epitopes of parasitic viroids based on multiple levels of proteomics, genomics, and metabolomics. Through these technologies, we can identify potential vaccine candidates and provide an important basis for the development of parasitic disease vaccines.

• Evaluation of vaccine immunization effectiveness

To ensure the immune efficacy of parasitic disease vaccines, effective evaluation is required. We can provide efficient technical services such as single-cell sequencing to reveal the molecular mechanism of the host immune response. In addition, we can provide a comprehensive and in-depth evaluation of vaccine immune efficacy using technologies such as flow cytometry and cellular immune separation, thereby providing important data to support vaccine development and improvement.

• Application of gene editing technologies in vaccine development

CRISPR/Cas9 technology has become one of the most commonly used gene editing tools today. We can use this technology to achieve gene knockout and gene modification to construct reliable vaccine candidates. In addition, we can also use technical services such as mutation screening to help our clients study the genetic diversity of parasite strains and their impact on vaccine resistance. These technical tools can effectively contribute to the development and optimization of parasitic disease vaccines.

• Application of omics technology in vaccine platform development

Based on the powerful means of omics technology, we can construct many different types of vaccine platforms. This includes different types of vaccine platforms based on RNA vaccines, DNA vaccines, protein subunit vaccines, and vector vaccines. We can provide the appropriate omics services to help our clients build the best vaccine platform according to their needs and provide data support for vaccine development and improvement.

• Immunomodulatory mechanism research

We can provide gene targeting and gene expression regulation services based on CRISPR/Cas9 and RNAi technologies for the immune regulation mechanism of parasitic diseases. These technical tools can help our clients to study the effect of parasitic virulence agents on the host immune system and thus provide solutions for vaccine design.

• Vaccine safety assessment

During the vaccine development process, a thorough evaluation of its safety is required. We can perform vaccine safety evaluation using various aspects such as cytotoxicity assay and drug metabolism pathway analysis to ensure the efficiency and safety of the vaccine.

• Construction of in vitro models and animal models

For different types of parasitic vaccine studies, we can provide in vitro or in vivo model construction services according to customer needs, such as conducting relevant tests on animal models such as mice, rats, and monkeys. These models can help clients to predict more accurately the immune effect of vaccines in humans and provide an important basis for vaccine improvement.

Ace Therapeutics provides solutions for parasitic vaccine development research, welcome to cooperate with us. We will provide our clients with professional, reliable, and high-quality services to ensure the success of their research projects. Please consult us to learn more.

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service