Parasitic diseases are important latent diseases that endanger human and livestock health and can be contracted through food/feed, drinking water, feces, physical contact as well as blood-sucking insects, and vertical transmission. The mechanism of parasitism in the host is complex, and available studies have shown that most parasites such as Trichinella, Plasmodium, Toxoplasma, and Trypanosoma can secrete exosomes, called worm-derived exosomes. Exosomes (containing proteins, lipids, and nucleic acids) are an important means of intercellular information exchange and play an important role in signaling, antigen presentation, immune regulation, metabolite clearance, and coagulation.

Worm-derived exosomes can serve as a link between the parasite and the host. On the one hand, the parasite produces exosomes in response to stimulation by multiple mechanisms. Exosomes encapsulate a large amount of worm-derived information into host body fluids and cells, which in turn modulates the host's immune system, suppresses the inflammatory response, and improves its parasitic environment. On the other hand, exosomes can carry toxic and harmful substances directly into the host's circulatory system. The mechanism of action of exosomes varies among different insect-derived exosomes.

Ace Therapeutics provides a one-stop shop for the multi-omics of exosomes of parasitic origin, including but not limited to genomics, epigenomics, transcriptomics, proteomics, metabolomics, and single-cell omics. From sample extraction, library construction, sequencing/assay to data analysis, each step is scientifically and carefully designed to ensure high-quality results.

Multi-Omics Service Options for Parasite-derived Exosomes

1. Proteomics

We provide proteomics of parasite-derived exosomes to our global customers based on advanced facilities and optimized operational procedures, helping to resolve biological issues such as the transmission of virulence factors, drug resistance genes, and differentiation factors between parasites, as well as the regulation of host gene expression and immune responses, and the involvement of parasites in the pathogenic process. Our technology includes iTRAQ/TMT labeled quantitative proteomics, label-free quantitative proteomics, DIA quantitative proteomics, qualitative identification proteomics, and qualitative modification proteomics.

2. Metabolomics and lipidomics

There is a complex information exchange between the parasite and the host, and the parasite can transfer bioactive substances into the host cells by secreting exosomes to regulate the host's immunity and mediate the immune escape of the parasite. If exosomes are used as drug carriers, they can block the transfer of parasites in host cells or enhance host immunity, providing new opportunities to prevent and treat parasitic diseases.

The metabolomics of parasite-derived exosomes can achieve dynamic changes in metabolite composition, abundance, and metabolic pathway resolution. Lipidomics of parasite-derived exosomes can comprehensively characterize lipid composition, abundance, saturation, chain length, etc. It helps reveal the pathogenesis of parasitic diseases, find biomarkers for disease diagnosis and prognosis, targets, and tools for disease treatment, and predict disease risk.

Service Details

• Sample type: parasitic tissues or exosomes that have been isolated. (Exosome isolation can be done by us or by you.)
• Delivery content: experiment report.
• Service fee: please get it through online inquiry.

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service