Pneumocystis is an opportunistic pathogen, and infections caused by it have been reported worldwide, but the prevalence and incidence of infection varies from country to country and region to region. Pneumocystis is often co-infected with HIV and is a major cause of death in AIDS patients. The life history of this worm is not fully understood. It is generally believed to develop in two periods, intracellular and extracellular, with both sexual and asexual reproduction, and to be completed in the same host. The mature encapsulation is the infective stage of the worm and is transmitted by air or droplet. After entering the lungs, the worms settle in the alveoli and adhere to the surface of the alveolar epithelium, causing an inflammatory response and a large amount of foamy exudate containing histiocytes, lymphocytes, and plasma cells, as well as accumulating clusters of trophozoites and cysts in the alveolar lumen. The large number of worms and exudates can cause pulmonary ventilation dysfunction if they obstruct the alveoli and bronchi, which can lead to respiratory failure and death in severe cases.

Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services for Pneumocystis carinii disease. This provides a good model for Pneumocystis carinii morphology, life history and especially the molecular biology and preparation of monoclonal antibodies provided a good model.

Customization Service Options for Animal Models of Pneumocystis carinii Infection

We can set up a Pneumocystis carinii disease model for you in ICR mouse or SD rat, it can be used for scientific research and drug research of Pneumocystis. If you want to know more, you are welcome to consult us.

• ICR mouse model of Pneumocystis
• SD rat model of Pneumocystis

Service Details

Model animal selection: SD rats weighing 200~250g or ICR mice weighing 25~30g.
Other key reagents: dexamethasone, tetracycline containing hydrochloric acid.
Delivery content: experiment report and Pneumocystis carinii disease animal model.
Test fee: please get it through online inquiry.

Service Flow

1. Communicate your project requirements with us via online inquiry or telephone.
2. Communicate the requirements (Number, degree of infection, etc.) of Pneumocystis carinii disease animal model customization, sign the contract and pay the deposit.
3. (Optional) Fill out the sample order and send the samples.
4. Develop Pneumocystis carinii disease animal model and prepare project experiment report.
5. Delivery of report and model.

Our Advantages

• We offer 2 murine species of Pneumocystis carinii disease models, it can be used for scientific research and drug research of Pneumocystis. If you have special needs, please consult us for customization.
• Our professional technicians have extensive experience in parasite animal model development.
• Advanced technology platform, scientific management system, and standard R&D procedures.
• In addition to Pneumocystis carinii animal model customization service, we also provide Pneumocystis carinii identification (Smear microscopy of sputum/bronchial secretions, skin puncture lung biopsy, bronchoscopic lung biopsy, open-chest lung biopsy, IFA assay, ELISA assay, complement binding assay, DNA probe assay, rDNA probe assay and PCR assay, etc.) and in vitro culture services.
• The project cycle time is short and the price is competitive.

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service