The life history of Leishmania spp. has a protoflagellate (promastigote) period and a flagellate-free (amastigote) period. The former is parasitic in the digestive tract of arthropods (whiteflies), while the latter is parasitic in the cells of mammals or reptiles and is transmitted through whiteflies. The common Leishmania parasites in humans are Leishmania donovani, Leishmania tropica and Leishmania braziliensis.

The non-flagellated body of Leishmania donovani is mainly parasitized in macrophages of liver, spleen, bone marrow, lymph nodes, etc. It often causes systemic symptoms, such as fever, hepatosplenomegaly, anemia, epistaxis, etc. Patients often have dark pigmentation on the skin and fever, so it is also called Kala-azar, which means black fever. It is rarely self-healing because of its strong pathogenicity, and death is often caused by co-morbidity if left untreated.

Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services for Leishmania donovani disease. This provides a good model for the morphology, life history and especially the molecular biology of Leishmania donovani and the study of black fever.

Customization Service Options for Animal Models of Leishmania donovani Infection

We can set up a Leishmania donovani disease model for you in mice, golden voles or long-clawed gerbils, it can be used for scientific research and drug research of Leishmania donovani. If you want to know more, you are welcome to consult us.

• Mouse model of Leishmaniasis donovani
• Golden voles model of Leishmania donovani
• Long-clawed gerbils model of Leishmania donovani

Service Details

Model animal selection: mice, golden voles or long-clawed gerbils
Source of parasites: isolation and purified from the spleen of the conserved golden vole
Method: intravenous injection of Leishmania donovani at the flagellar-free stage
Delivery content: experiment report and Leishmania donovani disease animal model
Test fee: please get it through online inquiry.

The ability of different Leishmania species to infect the same model animal varies; the susceptibility of different model animals to the same Leishmania species and the response to infection also varies; individual differences in model animals affect the pathogenesis. The individual differences in the model animals affect the pathogenesis of the disease. The model animals and the Leishmania parasites can be selected according to the needs. The models replicated by this method can be used for studies of immune mechanisms and vaccines for Leishmania donovani.

Service Flow

1. Communicate your project requirements with us via online inquiry or telephone.
2. Communicate the requirements (Number, degree of infection, etc.) of Leishmania donovani disease animal model customization, sign the contract and pay the deposit.
3. Fill out the sample order and send the samples (optional).
4. Develop Leishmania donovani disease animal model and prepare project experiment report.
5. Delivery of report and animal model.

Our Advantages

• We offer mouse models of Leishmania donovani that can be used for scientific research and drug research of Leishmania donovani. If you have special needs, please consult us for customization.
• Our professional technicians have extensive experience in parasite animal model development.
• Advanced technology platform, scientific management system, and standard R&D procedures.
• In addition to Leishmania donovani animal model customization service, we also provide Leishmania donovani identification (Bone marrow aspiration smear method, culture method, animal inoculation method, skin tissue examination method, direct agglutination test, IFA test, IHA test, ELISA test, DNA method, etc.) and in vitro culture services.
• The project cycle time is short and the price is competitive.

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service