Gene editing technology can effectively identify target molecules in parasites, and the use of classical transfection has allowed researchers to open new horizons in the study of gene-function relationships, while the introduction of CRISPR/Cas9 technology has played an important role in the study of parietal parasite genes, greatly improving the efficiency of gene editing and accelerating the progress of research on specific vaccines.

The continuous optimization and upgrading of the CRISPR/Cas9 system will better help scientists to understand parasites at the genetic level, so as to effectively combat parasitic diseases and safeguard human and animal health.

Ace Therapeutics specializes in parasitology and has established a parasite genetic engineering technology platform designed to provide genetic engineering services for a variety of parasitic diseases to clients worldwide. We can provide CRISPR/Cas9 gene editing services for Trypanosome, laying the foundation for in-depth elucidation of mechanistic studies.

CRISPR/Cas9 Trypanosomn Genome Editing Service Options

We established a CRISPR/Cas9 genomic modification method for Trypanosome, which can efficiently perform gene knockout, gene plus tag and nucleotide substitution modifications in Trypanosome. Based on this, the method was further developed to address the technical needs of multiple gene modifications in the study of Trypanosome gene function. It provides a panoramic view to understand the regulation of gene expression in the life cycle of Trypanosome. If you want to know more, you are welcome to consult us.

• Object: cell or Trypanosome model

We can provide CRISPR/Cas9 genomic modification services for different Trypanosome species, including but not limited to the following:

• Single gene knockout CRISPR/Cas9 system
• Exogenous gene insertion CRISPR/Cas9 system
• Gene tagging CRISPR/Cas9 system
• Multiple knockout CRISPR/Cas9 system
• Large-segment knockout CRISPR/Cas9 system
• Others

It successfully edited trypanosomes' genes and greatly shortened the experimental cycle, increased targeting loci, and extended the application of reverse genetics.

Applications

• Facilitate functional studies of Trypanosome genes.
• Contribute to research on Trypanosome resistance, drug targets and vaccines.

Service Details

Delivery content: experiment report and Trypanosome or Trypanosome animal models that edited by CRISPR/Cas9 technology
Test fee: please get it through online inquiry.

Service Flow

1. Communicate your requirements with us via online inquiry or telephone.
2. The client sends the experimental plan, such as knockout cells, knockout target genes.
3. Program evaluation and quotation, communication and determination of program details.
4. Communicate the requirements, sign the contract and pay the deposit.
5. Establish the needed Trypanosome CRISPR/Cas9 system and prepare experiment report. (All steps from vector design, construction, activity identification, and establishment of genetically mutated Trypanosome or model are completed in a one-stop shop.)
6. Delivery of report and Trypanosome edited by CRISPR/Cas9 technology.

Our Advantages

• Simple and fast target design.
• Efficient and flexible target manipulation.
• We have already had many years of successful experience in CRISPR/Cas9 system construction and activity validation.
• We have a strong technical support team and can provide free professional technical support for our customers.
• We have successfully used CRISPR/Cas9 system to provide thousands of successful cases for our customers. Our service is unanimously recognized by our customers.

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service